neuromodulatory role of bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (pbde -209) in neonate and young female mice
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abstract
objective(s):bacopa monnieri (bm),a traditional ayurvedic medicine,is a well-known memory enhancer. we have explored the role of bm against decabrominated diphenyl ether (pbde-209)-induced alterations in neonate and young female mice. materials and methods: mice were orally administered with b. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with pbde-209 (20 mg/kg body weight) from postnatal day (pnd) 3-10. levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. the correct choices and reference/working memory errors of young mice were evaluated by morris water and radial arm maze. results: the results showed that bm at the dose of 120 mg/kg significantly (p<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against pbde-209-induced toxicity. conclusion: bm plays a neuroprotective role against pbde-209-induced alterations in oxidative status.
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Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) f...
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Journal title:
iranian journal of basic medical sciencesجلد ۱۷، شماره ۴، صفحات ۳۰۷-۳۱۱
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